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72534Structure of Beta-secretase Complexed With Inhibitor
20504Crystal Structure of Beta-secretase Complexed With Inhibitor Om00-3
27428Crystal Structure of Unbound Beta-secretase Catalytic Domain
30330Crystal Structure of Human Beta Secretase Complexed With Inhibitor
29720APO Structure of Bace (Beta Secretase)
29721Bace (Beta Secretase) in Complex With a Nanomolar Non- Peptidic Inhibitor
32443NEW Substrate Binding Pockets for Beta-secretase
32444Crystal Structure of Beta-secretase Bound to a Long Inhibitor With Additional Upstream Residues
31168Crystal Structure of a Cycloamide-urethane-derived Novel Inhibitor Bound to Human Brain Memapsin 2 (Beta-secretase)
36959Crystal Structure of Human Beta Secretase Complexed With Nvp-aur200
36960Crystal Structure of Human Beta Secretase Complexed With Nvp-amk640
35708Crystal Structure of Human Beta Secretase Complexed With Inhibitor
36174Crystal Structure of Human Beta-secretase Complexed With L- L000430,469
40827Crystal Structure of the Bace Complex With Axq093, a Macrocyclic Inhibitor
40828Crystal Structure of the Bace Complex With Bdf488, a Macrocyclic Inhibitor
37347Crystal Structure of Beta-secretase Complexed With an Amino- Ethylene Inhibitor
38803Crystal Structure of Beta-secretase Bound to a Potent and Highly Selective Inhibitor
43854Crystal Structure of Human Beta-secretase (Bace) in the Presence of an Inhibitor
43857Crystal Structure of Human Beta-secretase (Bace) in the Presence of an Inhibitor (2)
44531Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-secretase (Bace)
43004Crystal Structure of Human Beta-secretase Complexed With Inhibitor
43005Crystal Structure of Human Beta-secretase Complexed With Inhibitor
60498Crystal Structure of Human Bace-1 Bound to Inhibitor
53945Crystal Structure of Human Beta Secretase Complexed With Inhibitor
45196X-ray Crystal Structure of Beta Secretase Complexed With Compound 5
45204X-ray Crystal Structure of Beta Secretase Complexed With 1- Amino-isoquinoline
45205X-ray Crystal Structure of Beta Secretase Complexed With 2- Aminoquinoline
45206X-ray Crystal Structure of Beta Secretase Complexed With N~3~-benzylpyridine-2,3-diamine
45207X-ray Crystal Structure of Beta Secretase Complexed With 4- (4-fluorobenzyl)piperidine
45520X-ray Crystal Structure of Beta Secretase Complexed With Compound 3
45208X-ray Crystal Structure of Beta Secretase Complexed With Compound 4
45209X-ray Crystal Structure of Beta Secretase Complexed With Compound 6A
45210X-ray Crystal Structure of Beta Secretase Complexed With Compound 6B
45211X-ray Crystal Structure of Beta Secretase Complexed With Compound 7
45212X-ray Crystal Structure of Beta Secretase Complexed With Compound 8B
54010Crystal Structure of Beta-secretase Bond to an Inhibitor With Isophthalamide Derivatives at P2-p3
46952Potent and Selective Isophthalamide S2 Hydroxyethylamine Inhibitor of Bace1
54028Crystal Structure of Human Beta Secretase Complexed With Inhibitor
46572Crystal Structure of Human Beta Secretase Complexed With Inhibitor
63896Crystal Structure of Human Beta Secretase Complexed With Inhibitor
54123Structure of Bace Complexed to Compound 1
54126Structure of Bace Complexed to Compound 3A
62920Structure of Bace1 Bound to Sch626485
62922Structure of Bace Bound to Sch722924
62923Structure of Bace Bound to Sch735310
63083Structure of Bace Bound to Sch745966
62924Structure of Bace Bound to Sch734723
65805Bace1 With Compound 1
65806Bace1 With Compound 2
64114Crystal Structure of Human Beta Secretase Complexed With I21
63929Crystal Structure of Human Beta Secretase Complexed With IXS
60621X-ray Crystal Structure of Beta Secretase Complexed With Compound 8C
60622X-ray Crystal Structure of Beta Secretase Complexed With Compound 24
60623X-ray Crystal Structure of Beta Secretase Complexed With Compound 27
62129Human Bace-1 in Complex With N-((1s,2r)-1-benzyl-2-hydroxy- 3-((1,1,5-trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2- Oxopyrrolidin-1-yl)benzamide
62130Human Bace-1 in Complex With 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(1,2,3,4-tetrahydro-1-naphthalenylamino) Propyl)benzamide
62131Human Bace-1 in Complex With N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide
62132Human Bace-1 in Complex With N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(2-oxo-1-pyrrolidinyl)-5-(propyloxy) Benzamide
62133Human Bace-1 in Complex With N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
62134Human Bace-1 in Complex With 3-(ethylamino)-n-((1s,2r)-2- Hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl) Methyl)amino)propyl)-5-(2-oxo-1-pyrrolidinyl)benzamide
62135Human Bace-1 in Complex With N-((1s,2r)-3-(cyclohexylamino)- 2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo- 1-pyrrolidinyl)benzamide
68488Crystal Structure of Grl-8234 Bound to Bace (Beta-secretase)
64519Human Bace-1 in Complex With 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)benzamide
64520Human Bace-1 in Complex With 7-ethyl-n-((1s,2r)-2-hydroxy-1- (Phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
72711Human Bace-1 in Complex With 1-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-4-(2-oxo-1-pyrrolidinyl)-1h-indole-6-carboxamide
72712Human Bace-1 in Complex With 4-ethyl-n-((1s,2r)-2-hydroxy-1- (Phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
72713Human Bace-1 in Complex With 7-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
72714Human Bace-1 in Complex With 8-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4,7,8-tetrahydro-1h,6h-(1,2,5) Thiadiazepino(5,4,3-de)quinoxaline-10-carboxamide 2,2- Dioxide
72715Human Bace-1 in Complex With 6-(ethylamino)-n-((1s,2r)-2- Hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-( Phenylmethyl)propyl)-1-methyl-1,3,4,5-tetrahydro-2,1- Benzothiazepine-8-carboxamide 2,2-dioxide
72563Human Bace-1 in Complex With 6-ethyl-1-methyl-n-((1s)-2-oxo- 1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)- 1,3,4,6-tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8- Carboxamide 2,2-dioxide
80364Human Bace (Beta Secretase) in Complex With Cyclohexanecarboxylic Acid (2-(2-am Ino-6-phenoxy-4h- Quinazolin-3-yl)-2-cyclohexyl-ethyl)-amide
83156Human Bace-1 in Complex With N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino) Benzamide
83157Human Bace-1 in Complex With N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
83158Human Bace-1 in Complex With N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)( Phenyl)amino)benzamide
68359X-ray Structure of Bace-1 in Complex With Compound 3.b.10
68360X-ray Structure of Bace-1 in Complex With Compound 6G
63980Crystal Structure of Bace1 in Complex With Om99-2 at PH 5.0
63981Crystal Structure of Bace1 at PH 4.0
63982Crystal Structure of Bace1 at PH 4.5
63983Crystal Structure of Bace1 at PH 5.0
63984Crystal Structure of Bace1 at PH 7.0
69112Crystal Structure of the Human Bace1 Catalytic Domain in Complex With N-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide
69113Crystal Structure of the Human Bace1 Catalytic Domain in Complex With N-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4- Mercapto-butyramide
69114Crystal Structure of the Human Bace1 Catalytic Domain in Complex With 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid (2-mercapto-ethyl)- Amide
69115Crystal Structure of the Human Bace1 Catalytic Domain in Complex With 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid(3-mercapto-propyl)-amide
69116Crystal Structure of the Human Bace1 Catalytic Domain in Complex With N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin- 4-yl]-4-mercapto-butyramide
69117Crystal Structure of the Human Bace1 Catalytic Domain in Complex With N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide
69118Crystal Structure of the Human Bace1 Catalytic Domain in Complex With N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide
62972Bace-1 Complexed With Compound 1
62974Bace-1 Complexed With Compound 2
62975Bace-1 Complexed With Compound 3
62976Bace-1 Complexed With Compound 4
64875Structure of Bace Bound to Sch727596
64876Structure of Bace Bound to Sch709583
64877Structure of Bace Bound to Sch726222
64787Crystal Structure of Bace-1 in Complex With Inhibitor
64788Crystal Structure of Bace-1 in Complex With Inhibitor
68541Beta-secretase 1 Complexed With Statine-based Inhibitor
69833Crystal Structure of Human Beta-secretase in Complex With Nvp-afj144
69834Crystal Structure of Human Beta-secretase in Complex With Nvp-arv999
69835Crystal Structure of Human Beta-secretase in Complex With Nvp-bav544
69430Crystal Structure of Bace1 Bound to Inhibitor
69200Crystal Structure of Human Beta Secretase Complexed With Spiropiperdine Iminohydantoin Inhibitor
75165Discovery of Aminoheterocycles as a Novel Beta-secretase Inhibitor Class
77830Structure of Bace (Beta Secretase) in Complex With EV0
77831Structure of Bace (Beta Secretase) in Complex With Ligand EV2
82447Potent Beta-secretase 1 Hydroxyethylene Inhibitor
77840Bace-1 With Compound 3
79445Bace1 With Compound 30
79446Bace1 With Compound 38
80449Bace1 With the Aminohydantoin Compound 29
80450Bace1 With the Aminohydantoin Compound S-34
80451Bace1 With the Aminohydantoin Compound 37
80452Bace1 With the Aminohydantoin Compound R-58
79137Design and Synthesis of Potent Bace-1 Inhibitors With Cellular Activity: Structure-activity Relationship of P1 Substituents
79138Design and Synthesis of Potent Bace-1 Inhibitors With Cellular Activity: Structure-activity Relationship of P1 Substituents
80459Crystal Structure of Beta-secretase 1 in Complex With Selective Beta-secretase 1 Inhibitor
84649Potent Beta-secretase 1 Inhibitor
80470Human Bace-1 Complex With Nb-216
81853Crystal Structure of Bace-1 in Complex With Ahm178
81854Human Bace-1 Complex With Ayh011
81855Human Bace-1 Complex With Bjc060
79485Structure of Bace Bound to Sch346572
79486Structure of Bace Bound to Sch12472
79487Structure of Bace Bound to Sch708236
87582Bace-1 in Complex With a Norstatine Type Inhibitor
81719Bace1 in Complex With the Aminopyridine Compound 44
81720Bace-1 With the Aminopyridine Compound 32
80183Structure of Bace Bound to Sch589432
80184Structure of Bace Bound to Sch710413
80185Structure of Bace Bound to Sch713601
80186Structure of Bace Bound to Sch723871
80187Structure of Bace Bound to Sch723873
80188Structure of Bace Bound to Sch736062
80189Structure of Bace Bound to Sch736201
81577Bace1 in Complex With the Aminohydantoin Compound 4G
81418Structure of Bace Bound to Sch743813
81420Structure of Bace Bound to Sch745132
81421Structure of Bace Bound to Sch743641
81422Structure of Bace Bound to Sch747123
83361Structure of Bace (Beta Secretase) in Complex With Inhibitor
83362Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
83363Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
86454Bace-1 in Complex With Eln380842
85049Bace-1 in Complex With Eln475957
89675Crystal Structure of Beta-site App-cleaving Enzyme 1 (Bace-wt) Complex With Bms-655295 AKA N~3~-((1s,2r)-1- Benzyl-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~, N~1~-dibutyl-1h-indole-1,3- Dicarboxamide
89676Crystal Structure of Beta-site App-cleaving Enzyme 1 (Bace-wt) Complex With Bms-681889 AKA N~1~-butyl-5-cyano- N~3~-((1s,2r)-1-(3,5- Difluorobenzyl)-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~- Methyl-1h-indole-1,3- Dicarboxamide
89404Crystal Structure of Human Beta Secretase in Complex With Bfg356
89415Structure Based Design, Synthesis and SAR of Cyclic Hydroxyethylamine (Hea) Bace-1 Inhibitors
91237Structure Basis of Allosteric Inhibition of Bace1 by an Exosite- Binding Antibody
91051Fragment Based Discovery and Optimisation of Bace-1 Inhibitors